Modeling and simulation of rapid expansion of supercritical solutions
نویسندگان
چکیده
منابع مشابه
Modeling and Simulation of Rapid Expansion of Supercritical Solutions
Rapid expansion of supercritical solution (RESS) is a promising technique for microparticle production. The literature points out that the RESS technique can be applied to process a wide range of materials including ceramics, polymers, biopolymers, pharmaceutics, and organic compounds. In order to achieve an adequate understanding of the RESS process, it is necessary to conduct more comprehensi...
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Molecular dynamics (MD) calculations have been performed to determine equilibrium structure and properties of systems modeling supercritical (SC) water and SC aqueous solutions at two states near the critical point using the simple point charge (SPC) potential model of Berendsen et al. for water. Both thermodynamic and dielectric properties from the simulations for pure water are accurate in co...
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The particle sizes of pharmaceutical substances are important for their bioavailability. Bioavailability can be improved by reducing the particle size of the drug. In this study, artemisinin was micronized by the rapid expansion of supercritical solutions (RESS). The particle size of the unprocessed white needle-like artemisinin particles was 30 to 1200 μm. The optimum micronization conditions ...
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Supercritical carbon dioxide has currently received a lot of attention as attractive media for the production of small and solvent-free particles. Rapid expansion of supercritical solutions (RESS) technique has been paid much attention and has been expected as an effective and environmentally friendly nanoparticle design method. In this study, the production of nanoparticles of RS-(±)-ibuprofen...
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Dissolution pressure and nozzle temperature effects on particle size and distribution were investigated for RESS (Rapid Expansion of Supercritical Solution) process. Supercritical CO2 was used as solvent and Ibuprofen was applied as the model component in all runs. The resulting Ibuprofen nano-particles (about 50 nm in optimized runs) were analyzed by SEM and laser diffraction pa...
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ژورنال
عنوان ژورنال: Brazilian Journal of Chemical Engineering
سال: 2006
ISSN: 0104-6632
DOI: 10.1590/s0104-66322006000300015